HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 18697971, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 18697971 | HCID 18697971 | — |
Reaction Steps
A solution of 4,6-dichloropyrimidine (5.22 g), ethyl isonipecotate (5.50 g) and triethylamine (7 ml) in ethanol (60 ml) was stirred at room temperature for 2 hours, and solvent removed in vacuo. The crude mixture partitioned between ethyl acetate (100 ml) and water (50 ml), washed with brine, dried (MgSO4) and solvent removed to give 1-(6-chloropyrimidin-4-yl)-4-(ethoxycarbonyl)piperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06093718 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-bd469e6bd82545cdbdeceb559027cfc4 |
| Source note | uspto-grants-2000_07 |