1-(4-Bromobenzene-1-sulfonyl)piperazine → 1-(4-Bromophenylsulphonyl)-4-[1-(2-ethylpyrimidin-4-yl)-4-methyl-piperidin-4-ylcarbonyl]piperazine

HRID 2289549Notes

Reaction equation

HRID 2289549 reaction equation
[CH2:1]([C:3]1[N:8]=[C:7]([N:9]2[CH2:14][CH2:13][C:12]([CH3:18])([C:15]([OH:17])=O)[CH2:11][CH2:10]2)[CH:6]=[CH:5][N:4]=1)[CH3:2].[Br:19][C:20]1[CH:25]=[CH:24][C:23]([S:26]([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)(=[O:28])=[O:27])=[CH:22][CH:21]=1>>[Br:19][C:20]1[CH:21]=[CH:22][C:23]([S:26]([N:29]2[CH2:34][CH2:33][N:32]([C:15]([C:12]3([CH3:18])[CH2:11][CH2:10][N:9]([C:7]4[CH:6]=[CH:5][N:4]=[C:3]([CH2:1][CH3:2])[N:8]=4)[CH2:14][CH2:13]3)=[O:17])[CH2:31][CH2:30]2)(=[O:28])=[O:27])=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 7129241-(4-Bromobenzene-1-sulfonyl)piperazineHCID 186980471-(2-Ethylpyrimidin-4-yl)-4-methyl-piperidine-4-carboxylic acid

Product 1

HCID 186980101-(4-Bromophenylsulphonyl)-4-[1-(2-ethylpyrimidin-4-yl)-4-methyl-piperidin-4-ylcarbonyl]piperazine

Procedure

In a similar process as described in Example 39 using 1-(2-ethylpyrimidin-4-yl)-4-methyl-piperidine-4-carboxylic acid and 1-(4-bromophenylsulphonyl)-piperazine the following was produced 1-(4-bromophenylsulphonyl)-4-[1-(2-ethylpyrimidin-4-yl)-4-methyl-piperidin-4-ylcarbonyl]piperazine.

Sources & evidence

ORD record
ord-b28606df24964a5ababc63cabea85d0e
Source dataset
uspto-grants-2000_07
Patent number
US06093718

Reaction notes

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