HCID 18698023, compound → 1,1-Dimethylethyl 4-[[1-(6-methyl-4-pyrimidinyl)-4-piperidinyl]carbonyl]-1-piperazinecarboxylate

Participants

Reaction Steps

A solution of 1-(tert-butoxycarbonyl)-4-[1-(2-chloro-6-methyl-pyrimidin-4-yl)-4-piperidylcarbonyl]piperazine (15.37 g) in ethanol (350 ml) was hydrogenated over 10% palladium on carbon for 18 hours. The reaction mixture was filtered through celite and solvent evaporated to give, as a solid 1-(tert-butoxycarbonyl)-4-[1-(6-methylpyrimidin-4-yl)-4-piperidylcarbonyl] piperazine (14.07 g).

Provenance & Evidence