HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-[1-(Tert-butoxycarbonyl)-piperazin-4-ylcarbonyl]-4-(6-chloro-pyrimidin-4-yl) piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Reactant | Tert-butyl 4-(piperazine-1-carbonyl)piperazine-1-carboxylate | HCID 18432746 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-[1-(Tert-butoxycarbonyl)-piperazin-4-ylcarbonyl]-4-(6-chloro-pyrimidin-4-yl) piperazine | HCID 54050451 | 98.4% |
Reaction Steps
A solution of 4,6-dichloropyrimidine (8.60 g), 1-[1-(tert-butoxycarbonyl)-piperazin-4-ylcarbonyl]piperazine 15.64 g) and triethylamine (21.95 ml) in ethanol (300 ml) was stirred at room temperature for 30 minutes. Solvent was evaporated and the residue dissolved in dichloromethane and washed with water, saturated aqueous sodium chloride solution, dried (Na2SO4) and evaporated to give, as a pale yellow solid 1-[1-(tert-butoxycarbonyl)-piperazin-4-ylcarbonyl]-4-(6-chloro-pyrimidin-4-yl) piperazine (21.20 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06093718 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-1a963b47e42446a4af3b6aacb81b30dd |
| Source note | uspto-grants-2000_07 |