HCID 18697866, compound → HCID 18697752, compound

Participants

Reaction Steps

To a solution of the 1:1 mixture (872 mg) of ethyl 4-(4-t-butoxycarbonylamino-2-nitrobenzoyl)-1-(4-methoxybenzyl)-1,2,3-triazole-5-carboxylate and ethyl 5-(4-t-butoxycarbonylamino-2-nitrobenzoyl)-1-(4-methoxybenzyl)-1,2,3-triazole-4-carboxylate, prepared in the step (b), in ethyl acetate (20 ml) was added 10% palladium on carbon (30 mg). The mixture was stirred under a hydrogen atmosphere overnight and filtered. The filtrate was concentrated under reduced pressure, and the resulting oil was purified by column chromatography on silica gel (toluene:ethyl acetate=2:1) to give ethyl 4-(2-amino-4-t-butoxycarbonylaminobenzoyl)-1-(4-methoxybenzyl)-1,2,3-triazole-5-carboxylate (c-1: less polar component (LP)) (217 mg) and a mixture (219 mg) of the compound c-1 and ethyl 5-(2-amino-4-t-butoxycarbonylaminobenzoyl)-1-(4-methoxybenzyl)-1,2,3-triazole-4-carboxylate (c-2: more polar component (MP)) (219 mg). c-1 (LP):

Provenance & Evidence