HCID 18697812, compound → HCID 18697912, compound

Participants

Reaction Steps

The 3:1 mixture (650 mg, 1.39 mmol) of ethyl 1-(4-methoxybenzyl)-4-(4-acetylamino-2-nitrobenzoyl)-1,2,3-triazole-5-carboxylate (b-1) and ethyl 1-(4-methoxybenzyl)-5-(4-acetylamino-2-nitrobenzoyl)-1,2,3-triazole-4-carboxylate (b-2) prepared in the above step (b) was dissolved in ethyl acetate (29 ml), 10% palladium on carbon (65 mg) was added to the solution, and the mixture was stirred under a hydrogen atmosphere at room temperature for four days. The reaction mixture was filtered through Celite, the filtrate was concentrated under reduced pressure, and the resultant precipitate was collected by filtration to give a 3:1 mixture (565.5 mg, 93%) of ethyl 4-(2-amino-4-acetylaminobenzoyl)-1-(4-methoxybenzyl)-1,2,3-triazole-5-carboxylate (c-1) and ethyl 5-(2-amino-4-acetylaminobenzoyl)-1-(4-methoxybenzyl)-1,2,3-triazole-5-carboxylate (c-2).

Provenance & Evidence