HCID 131721911, compound → HCID 18698767, compound

Participants

Reaction Steps

4-(Tert-butyl-dimethyl-silyloxymethyl)-1-phenyl-1H-pyridin-2-one from Step 3 (1.3 g) was dissolved in TBAF in 1M THF (15 mL). The clear reaction mixture was stirred for 16 hours. The reaction mixture was concentrated and purified on a column of silica eluting with 10% MeOH/EtOAc to yield 4-hydroxymethyl-1-phenyl-1H-pyridin-2-one as a tan solid. 1H NMR (400 MHz, CDCl3) δ 7.5-7.47 (m, 2H); 7.43 (d, 1H); 7.38-7.36 (m, 2H); 7.32-7.30 (d, 1H) 6.67 (s, 1H); 6.23 (d, 1H) 4.57 (d, 2H).

Provenance & Evidence