Iodobenzene → HCID 11516908, compound

HRID 2289622Notes

Reaction equation

HRID 2289622 reaction equation
Cl.[O:2]=[C:3]1[CH:8]=[C:7]([CH2:9][N:10]2[C:14]([CH2:15][C:16]3[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=3)=[CH:13][N:12]=[CH:11]2)[CH:6]=[CH:5][N:4]1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[Cl:30]C1C=C(I)C=CC=1.IC1C=CC=CC=1>>[Cl:30][C:26]1[CH:25]=[C:24]([N:4]2[CH:5]=[CH:6][C:7]([CH2:9][N:10]3[C:14]([CH2:15][C:16]4[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=4)=[CH:13][N:12]=[CH:11]3)=[CH:8][C:3]2=[O:2])[CH:29]=[CH:28][CH:27]=1

Participants

4

Reactant 3

HCID 11575IodobenzeneHCID 122691-Chloro-3-iodobenzeneHCID 131721912HCID 131721912, compound

Product 1

HCID 11516908HCID 11516908, compound

Procedure

4-{3-[1-(3-Chloro-phenyl)-2-oxo-1,2-dihydropyridin-4-ylmethyl]-3H-imidazol-4-ylmethyl}benzonitrile was prepared in a manner substantially similar to the procedure described above for 4-[3-(2-oxo-1-phenyl-1,2-dihydropyridin-4-ylmethyl)-3H-imidazol-4-ylmethyl]benzonitrile, hydrochloride, but substituting 3-chloroiodobenzene for the iodobenzene in Step 3.

Sources & evidence

ORD record
ord-6e92fb99165440c29ee59bad145ef8ed
Source dataset
uspto-grants-2000_07
Patent number
US06093737

Reaction notes

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