Iodobenzene → HCID 15895920, compound

HRID 2289624Notes

Reaction equation

HRID 2289624 reaction equation
Cl.[O:2]=[C:3]1[CH:8]=[C:7]([CH2:9][N:10]2[C:14]([CH2:15][C:16]3[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=3)=[CH:13][N:12]=[CH:11]2)[CH:6]=[CH:5][N:4]1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.BrC1C=CC=C(C)[N:32]=1.IC1C=CC=CC=1>>[CH3:29][C:28]1[N:32]=[C:24]([N:4]2[CH:5]=[CH:6][C:7]([CH2:9][N:10]3[C:14]([CH2:15][C:16]4[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=4)=[CH:13][N:12]=[CH:11]3)=[CH:8][C:3]2=[O:2])[CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 3

HCID 11575IodobenzeneHCID 792052-Bromo-6-methylpyridineHCID 131721912HCID 131721912, compound

Product 1

HCID 15895920HCID 15895920, compound

Procedure

4-[3-(6'-Methyl-2-oxo-2H-[1,2']bipyridinyl-4-ylmethyl)-3H-imidazol-4-ylmethyl]-benzonitrile was prepared in a manner substantially similar to the procedure described above for 4-[3-(2-oxo-1-phenyl-1,2-dihydropyridin-4-ylmethyl)-3H-imidazol-4-ylmethyl]benzonitrile, hydrochloride, but substituting 2-bromo-6-methylpyridine for the iodobenzene in Step 3.

Sources & evidence

ORD record
ord-5b1ffbc4365241159bb64c5b2a52b04f
Source dataset
uspto-grants-2000_07
Patent number
US06093737

Reaction notes

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