Iodobenzene → HCID 86755564, compound

HRID 2289626Notes

Reaction equation

HRID 2289626 reaction equation
Cl.[O:2]=[C:3]1[CH:8]=[C:7]([CH2:9][N:10]2[C:14]([CH2:15][C:16]3[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=3)=[CH:13][N:12]=[CH:11]2)[CH:6]=[CH:5][N:4]1C1C=CC=CC=1.Cl[C:31]1[CH:36]=[N:35][CH:34]=[C:33]([Cl:37])[N:32]=1.IC1C=CC=CC=1>>[Cl:37][C:33]1[N:32]=[C:31]([N:4]2[CH:5]=[CH:6][C:7]([CH2:9][N:10]3[C:14]([CH2:15][C:16]4[CH:17]=[CH:18][C:19]([C:20]#[N:21])=[CH:22][CH:23]=4)=[CH:13][N:12]=[CH:11]3)=[CH:8][C:3]2=[O:2])[CH:36]=[N:35][CH:34]=1

Participants

4

Reactant 3

HCID 11575IodobenzeneHCID 785042,6-DichloropyrazineHCID 131721912HCID 131721912, compound

Product 1

HCID 86755564HCID 86755564, compound

Procedure

4-{3-[1-(6-chloro-pyrazin-2-yl)-2-oxo-1,2-dihydro-pyridin-4-ylmethyl]-3H-imidazol-4ylmethyl}-benzonitrile was prepared in a manner substantially similar to the procedure described above for 4-[3-(2-oxo-1-phenyl-1,2-dihydropyridin-4-ylmethyl)-3H-imidazol-4-ylmethyl]benzonitrile, hydrochloride, but substituting 2,6-dichloropyrazine for the iodobenzene in Step 3.

Sources & evidence

ORD record
ord-234548a4197d40b48f636b21a1547934
Source dataset
uspto-grants-2000_07
Patent number
US06093737

Reaction notes

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