Iodobenzene → HCID 88249051, compound

HRID 2289630Notes

Reaction equation

HRID 2289630 reaction equation
Cl.[O:2]=[C:3]1[CH:8]=[C:7]([CH2:9][N:10]2[C:14]([CH2:15][C:16]3[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=3)=[CH:13][N:12]=[CH:11]2)[CH:6]=[CH:5][N:4]1[C:24]1C=CC=CC=1.ClC1[N:36]=[C:35]([Cl:37])[CH:34]=[C:33]([CH3:38])[N:32]=1.IC1C=CC=CC=1>>[Cl:37][C:35]1[N:36]=[C:24]([N:4]2[CH:5]=[CH:6][C:7]([CH2:9][N:10]3[C:14]([CH2:15][C:16]4[CH:17]=[CH:18][C:19]([C:20]#[N:21])=[CH:22][CH:23]=4)=[CH:13][N:12]=[CH:11]3)=[CH:8][C:3]2=[O:2])[N:32]=[C:33]([CH3:38])[CH:34]=1

Participants

4

Reactant 3

HCID 11575IodobenzeneHCID 794712,4-Dichloro-6-methylpyrimidineHCID 131721912HCID 131721912, compound

Product 1

HCID 88249051HCID 88249051, compound

Procedure

4-{3-[1-(6-Chloro-4-methyl-pyrimidin-2-yl)-2-oxo-1,2-dihydro-pyridin-4-ylmethyl]-3H-imidazol-4ylmethyl}-benzonitrile was prepared in a manner substantially similar to the procedure described above for 4-[3-(2-oxo-1-phenyl-1,2-dihydropyridin-4-ylmethyl)-3H-imidazol-4-ylmethyl]benzonitrile, hydrochloride, but substituting 2,4-dichloro-6-methylprimidine for the iodobenzene in Step 3.

Sources & evidence

ORD record
ord-016bb8a8d5174cfeb2a9bc0baf7446c5
Source dataset
uspto-grants-2000_07
Patent number
US06093737

Reaction notes

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