1-Trityl-4-(4-cyanobenzyl)imidazole → HCID 18698786, compound

HRID 2289631Notes

Reaction equation

HRID 2289631 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[CH:13]=[CH:12][C:11]([CH2:14][N:15]3[C:19]([CH2:20]C4C=CC(C#N)=CC=4)=[CH:18][N:17]=[CH:16]3)=[CH:10][C:9]2=[O:29])[CH:5]=[CH:4][CH:3]=1.[C:30]([N:49]1C=C(CC2C=CC(C#N)=CC=2)N=C1)(C1C=CC=CC=1)(C1C=CC=CC=1)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[CH:13]=[CH:12][C:11]([CH2:14][N:15]3[C:19]([CH2:20][C:33]4[CH:32]=[C:31]([CH:36]=[CH:35][CH:34]=4)[C:30]#[N:49])=[CH:18][N:17]=[CH:16]3)=[CH:10][C:9]2=[O:29])[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 158375331-Trityl-4-(4-cyanobenzyl)imidazoleHCID 18698787HCID 18698787, compound

Product 1

HCID 18698786HCID 18698786, compound

Procedure

3-[3-(6'-chloro-2-oxo-2H-[1,2']bipyridinyl-4-ylmethyl)-3H-imidazol-4-ylmethyl]-benzonitrile was prepared in a manner substantially similar to the procedure described above for 4-[3-(6'-chloro-2-oxo-2H-[1,2'] bipyridinyl-4-ylmethyl)-3H-imidazol-4-ylmethyl]-benzonitrile, but substituting 3-(1-trityl-1H-imidazol-4-ylmethyl)-benzonitrile for 4-(1-trityl-1H-imidazol-4-ylmethyl)-benzonitrile in Step 7.

Sources & evidence

ORD record
ord-c70ee271f19d4e958d2b6627fb553a0e
Source dataset
uspto-grants-2000_07
Patent number
US06093737

Reaction notes

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