Iodobenzene → HCID 18698790, compound

HRID 2289632Notes

Reaction equation

Cl.[O:2]=[C:3]1[CH:8]=[C:7]([CH2:9][N:10]2[C:14]([CH2:15][C:16]3[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=3)=[CH:13][N:12]=[CH:11]2)[CH:6]=[CH:5][N:4]1[C:24]1[CH:29]=CC=C[CH:25]=1.[C:30]([C:32]1[CH:33]=[N:34]C=C(Br)C=1)#[N:31].IC1C=CC=CC=1>>[C:33]([C:32]1[CH:29]=[C:24]([N:4]2[CH:5]=[CH:6][C:7]([CH2:9][N:10]3[C:14]([CH2:15][C:16]4[CH:17]=[CH:18][C:19]([C:20]#[N:21])=[CH:22][CH:23]=4)=[CH:13][N:12]=[CH:11]3)=[CH:8][C:3]2=[O:2])[CH:25]=[N:31][CH:30]=1)#[N:34]

Participants

Reactant 3

HCID 11575Iodobenzene

HCID 7367935-Bromonicotinonitrile

HCID 131721912HCID 131721912, compound

Product 1

HCID 18698790HCID 18698790, compound

Procedure

4-[3-(5'-Cyano-2-oxo-2H-[1,3']bipyridinyl-4-ylmethyl)-3H-imidazol-4-ylmethyl]-benzonitrile was prepared in a manner substantially similar to the procedure described above for 4-[3-(2-oxo-1-phenyl-1,2-dihydropyridin-4-ylmethyl)-3H-imidazol-4-ylmethyl]benzonitrile, hydrochloride, but substituting 3-cyano-5-bromopyridine for the iodobenzene in Step 3.

Sources & evidence

ORD record: ord-14c6f2dfc36740099cc4330d23670784
Source dataset: uspto-grants-2000_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06093737

Reaction notes

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