Iodobenzene → HCID 18698780, compound

HRID 2289634Notes

Reaction equation

HRID 2289634 reaction equation
Cl.[O:2]=[C:3]1[CH:8]=[C:7]([CH2:9][N:10]2[C:14]([CH2:15][C:16]3[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=3)=[CH:13][N:12]=[CH:11]2)[CH:6]=[CH:5][N:4]1C1C=CC=CC=1.Br[C:31]1[CH:36]=[CH:35][CH:34]=[C:33]([O:37][CH3:38])[N:32]=1.IC1C=CC=CC=1>>[CH3:38][O:37][C:33]1[N:32]=[C:31]([N:4]2[CH:5]=[CH:6][C:7]([CH2:9][N:10]3[C:14]([CH2:15][C:16]4[CH:17]=[CH:18][C:19]([C:20]#[N:21])=[CH:22][CH:23]=4)=[CH:13][N:12]=[CH:11]3)=[CH:8][C:3]2=[O:2])[CH:36]=[CH:35][CH:34]=1

Participants

4

Reactant 3

HCID 11575IodobenzeneHCID 2568102-Bromo-6-methoxypyridineHCID 131721912HCID 131721912, compound

Product 1

HCID 18698780HCID 18698780, compound

Procedure

4-[3-(6'-Methoxy-2-oxo-2H-[1,2']bipyridinyl-4-ylmethyl)-3H-imidazol-4-ylmethyl]-benzonitrile was prepared in a manner substantially similar to the procedure described above for 4-[3-(2-oxo-1-phenyl-1,2-dihydropyridin-4-ylmethyl)-3H-imidazol-4-ylmethyl]benzonitrile, hydrochloride, but substituting 2-bromo-6-methoxypyridine for the iodobenzene in Step 3.

Sources & evidence

ORD record
ord-74cf52ba64704f8fa071f3f9c7167ad9
Source dataset
uspto-grants-2000_07
Patent number
US06093737

Reaction notes

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