Hydrochloric Acid → HCID 70132136, compound

Participants

Reaction Steps

HCl (g) was bubbled through a solution of (S)-[5-tert-butoxycarbonylamino-5-(3,5-diisopropyl-4-{[(2,4,6-triisopropyl-phenyl)-acetyl]sulfamoyloxy}-phenylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester (1.08 g, 1.3 mmol) in 150 mL methanol for 30 minutes. The reaction was concentrated, and the resulting foam was triturated with 5% dichloromethane/hexanes to give 0.88 g (96%) of the title compound as a tan solid; mp 172-179° C.

Provenance & Evidence