HuagongsheHuagongshe Chemistry Print Report · For research reference only
Fmoc-Gly-OH → Acat-IN-5
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Fmoc-Gly-OH | HCID 93124 | — |
| Reactant | Acat-IN-2 | HCID 10142595 | — |
| Reactant | [(2,4,6-Triisopropyl-phenyl)-acetyl]-sulfamic acid 4-(aminomethylene)-2,6-diisopropyl-phenyl ester | HCID 53945870 | — |
| Solvent | piperidine N,N-dimethylformamide | HCID 23501187 | — |
| Product | Acat-IN-5 | HCID 10121195 | — |
Reaction Steps
When in the procedure of Example 1, bis-N,N'-(t-butoxycarbonyl)-(S)-lysine is replaced with N-(9-fluorenylmethyoxycarbonyl)-glycine, [(2,4,6-triisopropyl-phenyl)-acetyl]-sulfamic acid 4-amino-2,6-diisopropyl-phenyl ester is replaced by [(2,4,6-triisopropyl-phenyl)-acetyl]-sulfamic acid 4-(aminomethylene)-2,6-diisopropyl-phenyl ester, and the crude product is stirred in 20% piperidine/N,N-dimethylformamide for 0.5 hours followed by trituration with hexanes, the title compound is obtained; mp 193-195° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06093744 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-31342828ce694064beef1299d3976f51 |
| Source note | uspto-grants-2000_07 |