反应详情

3.9 mL of a 1 M solution of diisobutyl aluminum hydride in dichloromethane was added to a solution of 3,5-Diisopropyl-4-{[(2,4,6-triisopropyl-phenyl)-acetyl]sulfamoyloxy}-benzoic acid methyl ester (1.0 g, 1.8 mmol) in 125 mL dichloromethane at -78° C. After 3 hours, the reaction was warmed to room temperature and then quenched with a saturated aqueous sodium sulfate solution. The reaction mixture was filtered through a pad of celite, and the filtrate was concentrated to give a white foam. Triturated with 10% diethyl ether/hexanes to give 0.29 g of the title compound as a white solid; mp 163-168° C.

1. customquenched with a saturated aqueous sodium sulfate solution
2. filtrationThe reaction mixture was filtered through a pad of celite
3. concentrationthe filtrate was concentrated
4. customto give a white foam
5. customTriturated with 10% diethyl ether/hexanes