Trifluoroacetic acid → HCID 178512674, compound

Participants

Reaction Steps

N-[(4-Chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-L-phenylalanine t-butyl ester (30 mg, 0.060 mmol) was dissolved in CF3CO2H (2.5 mL) and the mixture stirred at room temperature for 2.5 h. The mixture was diluted with CH2Cl2 and PhMe, concentrated in vacuo, azeotroping with PhMe, and the residue triturated with Et2O to give N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-L-phenylalanine trifluoroacetate (24.4 mg, 0.42 mmol) as a white solid.

Provenance & Evidence