Hydrochloric Acid → HCID 178512648, compound

Participants

Reaction Steps

A partly heterogeneous solution of N-[(4-chloro-1-guanidino-7-isoquinolinyl)carbonyl]cycloleucine ethyl ester (45 mg, 0.11 mmol) in dioxane (1.5 mL) was stirred with aqueous NaOH (1 mL, 2 M) for 2.5 h at 23° C. Dilute HCl (1 mL, 2 M) was added to give a cream suspension. The solid was collected by filtration and dried in vacuo to yield N-[(4-chloro-1-guanidino-7-isoquinolinyl)carbonyl]cycloleucine (40 mg, 0.11 mmol).

Provenance & Evidence