反应详情

7-Bromo-1,4-dichloroisoquinoline ##STR100## A solution of 4-bromocinnamic acid (5.03 g, 22.2 mmol) in SOCl2 (15 mL) was stirred at 23° C. for 16 h, and then heated at reflux for a further 2 h. The solvents were evaporated in vacuo and the residue azeotroped with PhMe (×3) to yield 4-bromocinnamoyl chloride (22 mmol) as an orange-brown solid.

1. temperatureheated
2. temperatureat reflux for a further 2 h
3. customThe solvents were evaporated in vacuo
4. customthe residue azeotroped with PhMe (×3)