Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 3-(4-Bromophenyl)prop-2-enoyl chloride | HCID 53411293 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Bromocinnamoyl azide | HCID 53903424 | 94.1% |
Reaction Steps
A solution of NaN3 (2.2 g, 33.8 mmol) in water (7.5 mL) was added dropwise over 5 min to a stirred solution of 4-bromocinnamoyl chloride (22 mmol) in acetone (22 mL) at -10° C. The heterogeneous mixture was stirred at 0° C. for 1 h and diluted with water (25 mL). The precipitate was collected by filtration and dried in vacuo over P2O5 to give 4-bromocinnamoyl azide (5.22 g, 20.7 mmol) as a golden-coloured solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06093731 |
|---|
| Source dataset | uspto-grants-2000_07 |
|---|
| ORD ID | ord-d37bab554f7a4a4cb9176ed42dcbabd9 |
|---|
| Source note | uspto-grants-2000_07 |
|---|
