Triethylamine → HCID 18698336, compound

Participants

Reaction Steps

N-[(1,4-Dichloro-7-isoquinolinyl)sulphonyl]-N-(2-methylbenzyl)glycine 1-butyl ester ##STR121## 1,4-Dichloro-7-isoquinolinesulphonyl chloride (400 mg, 1.35 mmol) was added to a stirred solution of N-(2-methylbenzyl)glycine t-butyl ester (380 mg, 1.61 mmol) in CH2Cl2 (20 mL) containing NEt3 (0.28 mL, 2.5 mmol) under N2 and the mixture was stirred at room temperature for 18 h. The mixture was diluted with CH2Cl2 and washed with dilute HCl (2 M), saturated aqueous NaHCO3, brine, dried (MgSO4) then and evaporated in vacuo. The residue was purified by column chromatography upon silica gel using pentane-EtOAc (100:0 to 90:10) as eluant to give N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-(2-methylbenzyl)glycine t-butyl ester (480 mg, 0.97 mmol) as a white solid.

Provenance & Evidence