N-[(4-Chlorophenyl)methyl]-7-(dimethylamino)-4-hydroxy-3-quinolinecarboxamide → HCID 178482612, compound

HRID 2289917Notes

Reaction equation

HRID 2289917 reaction equation
NC1C=C2[C:9](=CC=1)[N:8]=[CH:7]C(C(NCC1C=CC(Cl)=CC=1)=O)=C2O.[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([CH2:31][NH:32][C:33]([C:35]2[CH:36]=[N:37][C:38]3[C:43]([C:44]=2[OH:45])=[CH:42][CH:41]=[C:40](N(C)C)[CH:39]=3)=[O:34])=[CH:27][CH:26]=1.NC1C=C2C(C(O)=C(C(NCC3C=CC(Cl)=CC=3)=O)C=N2)=CC=1>>[Cl:24][C:25]1[CH:26]=[CH:27][C:28]([CH2:31][NH:32][C:33]([C:35]2[CH:36]=[N:37][C:38]3[C:43]([C:44]=2[OH:45])=[CH:42][C:41]([N:8]([CH3:9])[CH3:7])=[CH:40][CH:39]=3)=[O:34])=[CH:29][CH:30]=1

Participants

4

Reactant 3

HCID 178482605N-[(4-Chlorophenyl)methyl]-7-(dimethylamino)-4-hydroxy-3-quinolinecarboxamideHCID 178507324HCID 178507324, compoundHCID 1785073346-amino-N-[(4-chlorophenyl)methyl]-4-hydroxy-3-quinolinecarboxamide

Product 1

HCID 178482612HCID 178482612, compound

Procedure

This compound is prepared from 6-amino-N-[(4-chlorophenyl)methyl]-4-hydroxy-3-quinolinecarboxamide using a procedure similar to that used to prepare N-[(4-chlorophenyl)methyl]-7-(dimethylamino)-4-hydroxy-3-quinolinecarboxamide from 7-amino-N-[(4-chlorophenyl)methyl]-4-hydroxy-3-quinolinecarboxamide (29805JT118). The product is obtained as a tan powder.

Workup

  1. customThe product is obtained as a tan powder

Sources & evidence

ORD record
ord-6ea15aab6d914ac2bfe4351a75bae256
Source dataset
uspto-grants-2000_07
Patent number
US06093732

Reaction notes

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