2,5-Dimethoxytetrahydrofuran → HCID 178522894, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 100 mg of 7-amino-N-[(4-chlorophenyl)methyl]-4-hydroxy-3-quinolinecarboxamide and 0.043 mL 2,5-dimethoxytetrahydrofuran in 1 mL of acetic acid is refluxed for four hours. (The mixture rapidly turned very dark.) It is cooled to 25° C. and the precipitate is collected by filtration. It is washed with three 1 mL portions of acetic acid and dried in a stream of air. After drying at 75° C. the product is obtained as 20 mg of a brown powder.

Provenance & Evidence