Isopropanol → HCID 178458751, compound

Participants

Reaction Steps

N-((4-Chlorophenyl)methyl)-4-hydroxy-6,7,8-trifluoro-3-quinolinecarboxamide (500 mg) from Example No. 15 and sodium hydride (60% dispersion, 109 mg) are dissolved in DMF (10 mL) and to the mixture is added 2-propanol (115 μL). After being heated for 1 h, additional sodium hydride (50 mg) is added, and the mixture is heated for an additional 1 h. The reaction mixture is allowed to cool to rt, poured into sat. aq. ammonium chloride (25 mL), and is filtered. The crude product is purified by column chromatography (dichloromethane/methanol, 100/1) to afford 62 mg of the title compound as a white solid.

Provenance & Evidence