Hydrochloric Acid → HCID 178525330, compound

Participants

Reaction Steps

To a mixture of the title compound of Example 113 (0.250 g) and triethylamine (0.09 mL) in 100 mL of 3:1 CH2Cl2MeOH is added 10% Pd/C (0.050 g). The mixture is hydrogenated at 30 psi H2 for 6 h. The reaction is filtered through celite and the filtrate is condensed. The crude product is dissolved in DMF (~25 mL) and acidified with 1 N HCl (25 mL). The resulting solid is collected, dried and recrystallized from EtOH to yield 0.152 g of the desired product as a white solid.

Provenance & Evidence