4-Pentynoic acid → HCID 178525391, compound

Participants

Reaction Steps

To a mixture of the title compound of Example 5 (0.457 g), copper iodide (0.010 g) and dichlorobis(triphenylphosphine)palladium (II) (0.035 g) in 15 mL diethylamine is added 4-pentynoic acid (0.098 g). The reaction is allowed to stir overnight. The solvents are evaporated and the residue is chromatographed on silica, eluting with 10% MeOH/CH2Cl2. Fractions homogeneous by TLC are combined and condensed. The residue is recrysallized from acetone/hexanes to yield 0.057 g of the desired product as a tan solid.

Provenance & Evidence