反应详情

N-(4-Chlorobenzyl)-4-hydroxy-6-(3-hydroxy-1-propynyl)-8-methoxy-3-quinolinecarboxamide (397 mg) from Example No. 118 is dissolved in methanol/dichloromethane (1/1, 80 mL) and palladium on carbon (5%, 80 mg) are --added. The mixture is placed under a hydrogen atmosphere (23 psi) for 1 h, filtered through celite, and concentrated. The crude product is purified by column chromatography (dichloromethane/methanol, 50/1 to 20/1) to afford 251 mg (63%) of the title compound as a white solid.

1. additionadded
2. customfor 1 h
3. filtrationfiltered through celite
4. concentrationconcentrated
5. customThe crude product is purified by column chromatography (dichloromethane/methanol, 50/1 to 20/1)