Methanol → HCID 178522904, compound

Participants

Reaction Steps

A mixture of N-(4-chlorobenzyl)-8-fluoro-4-hydroxy-6-(5-hydroxy-1-pentynyl)-3-quinolinecarboxamide from Example 107 (230 mg) and Pd/C (10%, 46.0 mg) is dissolved in 3:1 CH2Cl2 :MeOH. The reaction mixture is placed under the Parr hydrogenator at 38 psi H2 and monitored by mass spectroscopy for complete reduction of the acetylene. The reaction is complete in 11/2 h and filtered over celite to remove the palladium. The filtrate is condensed to afford 129.3 mg (56%) of the title compound as a white solid.

Provenance & Evidence