4-Chlorobenzylamine → HCID 178426083, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3.0 g of ethyl 6-chloro-4-hydroxy-8-methyl-3-quinolinecarboxylate (Maybridge Chemical Co.) and 7.0 mL of 4-chlorobenzylamine is stirred 3 h at 190° C. The mixture is cooled to 25° C. and is diluted with 35 mL of hexanes. The precipitate is collected by filtration and washed with 10 mL of hexanes. It is dried in a stream of air and then it was recrystallized from 30 mL of glacial acetic acid. It was dried at 20 torr and 100° C. for 20 h. The yield is 1.6 g (40%).

Provenance & Evidence