D-1,4-Dithiothreitol → HCID 178469648, compound

Participants

Reaction Steps

A mixture of 20 g of ethyl 6-(cyanosulfanyl)-8-fluoro-4-hydroxy-3-quinolinecarboxylate from preparation No. 16, 125 mL of DMF and 12.6 g of dithiothreitol is stirred for 5 h at 25° C. It is poured into 1 L of deoxygenated ice water and the precipitate collected by filtration, washed with two 200 mL portions of distilled water, and then dried in a stream of nitrogen. The title compound is obtained as 10.5 g of a white solid.

Provenance & Evidence