Diphenyl Ether → HCID 178469578, compound

Participants

Reaction Steps

To a flask containing diethyl 2-[(4-{[2-(acetyloxy)ethyl]amino}anilino)-methylene]-malonate (0.18 g) is added diphenyl ether (2 mL). The reaction mixture is heated from room temperature to 250° C. over 30 minutes under a flow of argon gas. The reaction is cooled to room temperature and filtered. The collected precipitate is washed repeatedly with methanol:dichloromethane and the filtrate is concentrated under reduced pressure. The residue is adsorbed onto silica and chromatographed on silica eluting with 5% to 50% methanol in dichloromethane. The product-containing fractions are evaporated to give 0.04 g of ethyl 6-{[2-(acetyloxy)ethyl]amino}-4-hydroxy-3-quinolinecarboxylate.

Provenance & Evidence