4-Chlorobenzylamine → HCID 178522882, compound

Participants

Reaction Conditions

Reaction Steps

To a flask containing ethyl 6-{[2-(acetyloxy)ethyl]amino)-4-hydroxy-3-quinolinecarboxylate (0.04 g) is added p-chlorobenzylamine (0.5 mL). The reaction is tightly capped and heated to 160° C. overnight. The reaction is cooled to room temperature, adsorbed onto silica and chromatographed on silica eluting with 3% to 10% methanol in dichloromethane. The product-containing fractions are evaporated to give 0.02 g of the title compound as a yellow solid.

Provenance & Evidence