Diphenyl Ether → HCID 178469570, compound

Participants

Reaction Conditions

Reaction Steps

To a flask containing diethyl 2-{[4-(2-oxo-1,3-oxazolidin-3-yl)anilino]-methylene}-malonate (0.46 g) is added diphenyl ether (6 mL). The reaction mixture is heated from room temperature to 235° C. over 2 hours under a flow of argon gas. After 1 hour at 235° C. the reaction is cooled to room temperature, diluted with diethyl ether and filtered. The collected precipitate is washed repeatedly with diethyl ether then dried in vacuo to give 0.17 g of ethyl 4-hydroxy-6-(2-oxo-1,3-oxazolidin-3-yl)-3-quinolinecarboxylate as a tan solid.

Provenance & Evidence