4-Chlorobenzylamine → HCID 178522881, compound

Participants

Reaction Conditions

Reaction Steps

To a flask containing ethyl 4-hydroxy-6-(2-oxo-1,3-oxazolidin-3-yl)-3-quinolinecarboxylate (0.17 g) is added p-chlorobenzylamine (1.0 mL). The reaction is tightly capped and heated to 185° C. over 1 hour. The reaction is cooled to room temperature and triturated with diethyl ether. The residue is adsorbed onto silica and chromatographed on silica eluting with 3% to 12% methanol in dichloromethane. The product-containing fractions are evaporated to give 0.12 g of the title compound as a off-white solid.

Provenance & Evidence