Hexane → HCID 178522865, compound

HRID 2290043Notes

Reaction equation

HRID 2290043 reaction equation
[PH:1](=[O:33])([O:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][CH:20]=1)[N:17]=[CH:16][C:15]([C:21]([NH:23][CH2:24][C:25]1[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=1)=[O:22])=[C:14]2[OH:32])[O:2]C(C)(C)C.CCCCCC>C(O)(C(F)(F)F)=O.ClCCl>[PH:1](=[O:2])([OH:33])[O:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][CH:20]=1)[N:17]=[CH:16][C:15]([C:21]([NH:23][CH2:24][C:25]1[CH:26]=[CH:27][C:28]([Cl:31])=[CH:29][CH:30]=1)=[O:22])=[C:14]2[OH:32]

Participants

4

Reactant 2

HCID 8058HexaneHCID 178454808HCID 178454808, compound

Product 1

HCID 178522865HCID 178522865, compoundYield 103%

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

A solution of 50.0 mg of tert-butyl 3-(3-{[(4-chlorobenzyl)amino]carbonyl}-4-hydroxy-6-quinolinyl)propyl phosphonate from Example No. 270 in 0.5 mL of 1:1 TFA-dichloromethane is stirred for 2 h, then added slowly to 20 mL of rapidly stirred hexane. The resulting solution was concentrated under reduced pressure to provide 45.6 mg of the title compound as a white crystalline solid.

Workup

  1. concentrationThe resulting solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-500e95bcc7c44bcb8b9f6b92091b0ed1
Source dataset
uspto-grants-2000_07
Patent number
US06093732

Reaction notes

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