Cesium carbonate → HCID 15454084, compound

Participants

Reaction Steps

Following general procedure E and using 5-amino-3,3-dimethyl-7-ethyl-2,3-dihydrobenzofuran (Compound 12, 0.22 g, 1.15 mmol), ethyl-4-iodo-benzoate (0.318 g, 115 mmol), cesium carbonate (0.525 g, 1.61 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.020 g, 0.021 mmol), (S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (0.040 g, 0.064 mmol) in 5 mL of anhydrous toluene, the title compound (0.3 g, 77%) was obtained as a deep yellow solid. 1H NMR (300 MHz, CDCl3): δ 7.88 (d, 2H, J=8.8 Hz), 6.79 (m, 4H), 5.92 (br s, 1H), 4.32 (q, 2H, J=7.2 Hz), 4.25 (s, 2H), 2.59 (q, 2H, J=7.5 Hz), 1.36 (t, 3H, J=7.2 Hz), 1.33 (s, 6H), 1.21 (t, 3H, J=7.5 Hz).

Provenance & Evidence