Methyl iodide → HCID 15454090, compound

Participants

Reaction Steps

Following general procedure G and using 4-[(3,3-dimethyl-7-ethyl-2,3-dihydro-benzofuran-5-yl)-amino]-benzoic acid ethyl ester (Compound 16, 0.18 g, 0.53 mmol), potassium carbonate (0.73 g, 5.3 mmol) and iodomethane (0.83 g, 5.3 mmol) in 2 mL of anhydrous N,N-dimethylacetamide, the title compound (0.134 g, 68%) was obtained as a pale yellow oil. The reaction was performed in a sealed tube. 1H NMR (300 MHz, CDCl3): δ 7.82 (d, 2H, J=9.0 Hz), 6.79 (d, 1H, J=2.0 Hz), 6.76 (d, 1H, J=2.0 Hz), 6.57 (d, 2H, J=9.0 Hz), 4.31 (q, 2H, J=7.1 Hz), 4.27 (s, 2H), 3.72 (q, 2H, J=7.1 Hz), 2.60 (q, 2H J=7.6 Hz), 1.35 (t, 3H, J=7.1 Hz), 1.33 (s, 6H), 1.26-1.19 (m, 6H).

Provenance & Evidence