Methyl iodide → HCID 54333640, compound

Participants

Reaction Steps

Following general procedure G and using 4-[(7-t-butyl-3,3-dimethyl-2,3-dihydro-benzofuran-5-yl)-amino]-benzoic acid ethyl ester (Compound 18, 0.15 g, 0.41 mmol), potassium carbonate (1.65 g, 12 mmol) and iodomethane (0.94 g, 6 mmol) in 5 mL of anhydrous N,N-dimethylacetamide, the title compound (0.090 g, 56%) was obtained as a pale yellow oil. 1H NMR (300 MHz, CDCl3): δ 7.85 (d, 2H, J=8.9 Hz), 6.87 (d, 1H, J=2.2 Hz), 6.77 (d, 1H, J=2.2 Hz), 6.57 (d, 2H, J=9.1 Hz), 4.29 (q, 2H, J=7.1 Hz), 4.28 (s, 2H), 3.74 (q, 2H, J=7.0 Hz), 1.36 (t, 3H, J=7.1 Hz), 1.36 (s, 9H), 1.33(s, 6H), 1.26 (t, 3H, J=7.1 Hz)).

Provenance & Evidence