Sodium Hydroxide → HCID 9927865, compound

Participants

Reaction Steps

Following general procedure I and using 4-[ethyl-(3,3-dimethyl-7-ethyl-2,3-dihydro-benzofuran-5-yl)-amino]-benzoic acid ethyl ester (Compound 22, 0.134 g, 0.36 mmol) and 2 mL of 5M sodium hydroxide solution in 2 mL of ethanol, the title compound (0.071 g, 58%) was obtained as a white solid. 1H NMR (300 MHz, CDCl3): δ 7.88 (d, 2H, J=9.0 Hz), 6.80 (d, 1H, J=2.0 Hz), 6.76 (d, 1H, J=2.0 Hz), 6.58 (d, 2H, J=9.0 Hz), 4.29 (s, 2H), 3.73 (q, 2H, J=7.1 Hz), 2.60 (q, 2H J=7.5 Hz), 1.34 (s, 6H), 1.27-1.12 (m, 6H).

Provenance & Evidence