Potassium Hydroxide → 4-[Methyl-(3,3-dimethyl-7-isopropyl-2,3-dihydro-benzofuran-5-yl)-amino]-benzoic acid

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Reaction Steps

Following general procedure I and using 4-[methyl-(3,3-dimethyl-7-isopropyl-2,3-dihydro-benzofuran-5-yl)-amino]-benzoic acid ethyl ester (Compound 23, 0.03 g, 0.081 mmol) and 2 mL of 5M potassium hydroxide solution in 10 mL of ethanol, the title compound (0.022 g, 79%) was obtained as a white solid. 1H NMR (300 MHz, CDCl3): δ 7.90 (d, 2H, J=9.0 Hz), 6.85 (d, 1H, J=2.2 Hz), 6.78 (d, 1H, J=2.2 Hz), 6.63 (d, 2H, J=9.0 Hz), 4.27 (s, 2H), 3.33 (s, 3H), 3.09 (heptet, 1H, J=6.8 Hz), 1.33 (s, 6H), 1.23 (d, 6H, J=6.8 Hz).

Provenance & Evidence