Cesium carbonate → HCID 53937827, compound

Participants

Reaction Steps

Following general procedure E and using 7-t-butyl-3,3-dimethyl-5-(isopropyl)amino-2,3-dihydro-benzofuran (Compound 36, 0.63 g, 2.4 mmol), ethyl-4-iodo-benzoate (0.62 3 g, 2.9 mmol), cesium carbonate (1.12 g, 3.4 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.025 g, 0.025 mmol) and (S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (0.050 g, 0.079 mmol) in 10 mL of anhydrous toluene, the title compound (0.15 g) contaminated with 67% of 7-t-butyl-3,3-dimethyl-5-(isopropyl)amino-2,3-dihydro-benzofuran (Compound 36) was obtained.

Provenance & Evidence