Potassium Hydroxide → HCID 9798648, compound

Participants

Reaction Steps

Following general procedure I and using 4-[isopropyl-(3,3-dimethyl-7-ethyl-2,3-dihydro-benzofuran-5-yl)-amino]-benzoic acid ethyl ester (Compound 38, 0.21 g, 0.55 mmol) and 2 mL of 5M potassium hydroxide solution in 10 mL of ethanol, the title compound (0.16 g, 88%)was obtained as a white solid. 1H NMR (300 MHz, CDCl3): δ 7.86 (d, 2H, J=9.1 Hz), 6.69 (d, 1H, J=2.0 Hz), 6.65 (d, 1H, J=2.0 Hz), 6.51 (d, 2H, J=9.1 Hz), 4.35 (heptet, 1H, J=6.5 Hz), 4.30 (s, 2H), 2.60 (q, 2H, J=7.5 Hz), 1.33 (s, 6H), 1.21 (t, 3H, J=7.5 Hz), 1.15 (d, 6H, J=6.5 Hz).

Provenance & Evidence