Potassium Hydroxide → HCID 9842914, compound

Participants

Reaction Steps

Following general procedure H and using 4-[isopropyl-(7-t-butyl-3,3-dimethyl-2,3-dihydro-benzofuran-5-yl)-amino]-benzoic acid ethyl ester (Compound 40, 0.1 5 g contaminated with 67% of 5-(isopropyl)amino-7-t-butyl-3,3-dimethyl-2,3-dihydro-benzofuran (Compound 36) and 2.5 mL of 4M potassium hydroxide solution in 4 mL of ethanol, the title compound (0.034 g, 3.7% for 2 steps) was obtained. 1H NMR (300 MHz, CDCl3): δ 7.86(d, 2H, J=9.0 Hz), 6.75 (d, 1H, J=2.1 Hz), 6.66 (d, 1H, J=2.1 Hz), 6.51 (d, 2H, J=9.1 Hz), 4.36 (heptet, 1H, J=6.5 Hz), 4.28 (s, 2H), 1.34 (s, 9H), 1.32(s, 6H), 1.15 (d, 6H, J=6.5 Hz).

Provenance & Evidence