Sodium Hydroxide → HCID 18699188, compound

Participants

Reaction Steps

Following general procedure P and using 4-[isopropyl-(7-isopropyl-3,3,6-trimethyl-2,3-dihydro-benzofuran-5-yl)-amino]-benzoic acid methyl ester (Compound 67, 0.037 g, 0.096 mmol) and 1.5 mL (7.5) of 5M sodium hydroxide in 5 mL of methanol, the title compound (0.027 g, 72%) was obtained, after flash column chromatography using 15% ethyl acetate in hexanes as the eluent, as a pale yellow solid. 1H NMR (300 MHz, CDCl3): δ 7.87 (d, 2H, J=8.9 Hz), 6.59 (s, 1H), 6.42 (d, 2H, J=8.9 Hz), 4.34 (heptet, 1H, J=6.3 Hz), 4.24 (s, 2H), 3.19 (heptet, 1H, J=7.0 Hz), 1.36-1.26 (m, 15H), 0.99 (d, 3H, J=6.53 Hz).

Provenance & Evidence