Methyl chloroformate → HCID 20231711, compound

HRID 2290172Notes

Reaction equation

HRID 2290172 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]1[NH:13][C:14]([CH:19]([CH3:21])[CH3:20])([CH3:18])[C:15](=[O:17])[N:16]=1)=[O:5])[CH3:2].Cl[C:23]([O:25][CH3:26])=[O:24]>N1C=CC=CC=1>[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]1[N:13]([C:23]([O:25][CH3:26])=[O:24])[C:14]([CH:19]([CH3:20])[CH3:21])([CH3:18])[C:15](=[O:17])[N:16]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 6586Methyl chloroformateHCID 178468792HCID 178468792, compound

Product 1

HCID 20231711HCID 20231711, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

8 g (0.028 mole) of 2-(2-ethoxycarbonylphenyl)-5-isopropyl-5-methyl-4-oxo-2-imidazoline are dissolved in 30 ml of absolute pyridine, and 5.3 g (0.056 mole) of methyl chloroformate are added at room temperature. After 1 hour, the mixture is poured onto ice and extracted twice with 100 ml of toluene each time and the organic phase is washed twice with water, dried and evaporated. 8.7 g (90% of theory) of 2-(2-ethoxycarbonylphenyl)-5-isopropyl-1-methoxycarbonyl-5-methyl-4-oxo-2-imidazoline are obtained as a colorless oil.

Workup

  1. additionthe mixture is poured onto ice
  2. extractionextracted twice with 100 ml of toluene each time
  3. washthe organic phase is washed twice with water
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-612c5378205e4e5b835aa00e3e391e34
Source dataset
uspto-grants-1986_10
Patent number
US04615726

Reaction notes

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