Acetic Acid → HCID 86741053, compound

Participants

Reaction Steps

The title compound was prepared with material from Example 6, (S)-N6 -[Dihydroxypropylisopropylidene]adenosine (2.3 g, 6 mmol). This was placed in 20% acetic acid in 1:1 methanol:water (100 ml), and stirred at ambient temperature for 22 hours. After removal of solvents, the residue was treated with acetone and the resulting percipitate filtered and dried in vacuo. This was then redissolved in 15% acetic acid, 1:1 water:methanol and stirred another 48 hours. Removal of solvents and vacuum drying at 85° yielded 0.77 g final product. m.p. 231°-5°

Provenance & Evidence