Pyridine → 1-Chloroethyl Cyclohexyl Carbonate

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Reaction Steps

A solution of 1.83 g of cyclohexanol and 1.45 g of pyridine in 30 ml of methylene chloride is cooled to -78° C. and 2.0 ml of 1-chloroethyl chloroformate is added dropwise, while stirring, over 10 minutes. Thereafter, the cold bath is removed and the mixture is stirred at room temperature for 16 hours, washed with three 30-ml portions of saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is then distilled off under reduced pressure to give 3.31 g (88% in yield) of the title compound as a colorless oil.

Provenance & Evidence