Hydrochloric Acid → HCID 13490826, compound

Participants

Reaction Steps

To a solution of 9 g of N-(1-benzyl-4-piperidyl)-1-butyl-5-hydroxy-2-methylindole-3-carboxamide in 100 ml of methanol were added 5 g of an 18% hydrochloric acid in ethanol and 4 g of 10% palladium carbon, and the mixture was subjected to catalytic hydrogenation at atmospheric pressure for 6 hours. After the catalyst was filtered off, the filtrate was concentrated under reduced pressure. The residue was crystallized with ethyl acetate and the resulting crystals were recrystallized from ethanol to give 4 g of 1-butyl-5-hydroxy-2-methyl-N-(4-piperidyl)indole-3-carboxamide hydrochloride, melting at 164°-168° C.

Provenance & Evidence