HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochlorothiazide → 2-(2-Bromoethyl)-6-chloro-3,4-dihydro-1,1-dioxo-7-sulfamoyl-1,2,4-benzothiadiazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochlorothiazide | HCID 3639 | — |
| Reactant | 1,2-Dibromoethane | HCID 7839 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Benzylbromoacetate | HCID 21881508 | — |
| Product | 2-(2-Bromoethyl)-6-chloro-3,4-dihydro-1,1-dioxo-7-sulfamoyl-1,2,4-benzothiadiazine | HCID 14280971 | — |
Reaction Steps
Treat 6-chloro-3,4-dihydro-1,1-dioxo-7-sulfamoyl-1,2,4-benzothiadiazine with Cs2CO3 and substitute 1,2-dibromoethane for benzylbromoacetate in the procedure of Example 7, step A to obtain 2-(2-bromoethyl)-6-chloro-3,4-dihydro-1,1-dioxo-7-sulfamoyl-1,2,4-benzothiadiazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04616012 |
| Source dataset | uspto-grants-1986_10 |
| ORD ID | ord-b54ea8e032f44142a233e07b8a99a882 |
| Source note | uspto-grants-1986_10 |